Enterochromaffin cells as the source of melatonin: key findings and functional relevance in mammals
Melatonin and enterochromaffin cells
Keywords:
Gastrointestinal (GI) tract, enterochromaffin (EC) cells, oxidative stress, melatonin, inflammation, enteric microbiota.
Abstract
The enteroendocrine cells in gastrointestinal (GI) tract synthesize more than thirty hormones in mammals. Among these cells, the enterochromaffin (EC) cells are probably the most important one due to the fact that they produce melatonin. The rate-limiting enzymes for melatonin synthesis including arylalkylamine-N-acetyltransferase (AANAT, currently the SNAT) and hydroxyindole-O-methyltransferase (HIOMT, currently the ASMT) have been identified in EC cells and this has confirmed the local melatonin production in GI tract by these cells. EC cells play a critical role in regulation of gastrointestinal physiology, particularly, in protection of the GI tract from free radical attack and inflammatory reaction. GI tract is the major site exposed to the oxidative stress and inflammation because of the food residue metabolism and the presence of trillions of microbes including the pathological bacteria. Thus, it requires strong protection. Melatonin synthesized by the EC cells provides the onsite protection in GI tract since this molecule is the potent free radical scavenger and effective ant-inflammatory agent. In this review we summarize the available information regarding the structural and functional variability of the EC cells as well as their pathophysiological roles in the GI tract. The focus is given to the protective effects of melatonin produced by the EC cells on the oxidative stress, inflammation and microbiota balance in GI tract.
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Published
2019-12-15
How to Cite
[1]
Pal, P.K., Sarkar, S., Chattopadhyay, A., Tan, D.X. and Bandyopadhyay, D. 2019. Enterochromaffin cells as the source of melatonin: key findings and functional relevance in mammals. Melatonin Research. 2, 4 (Dec. 2019), 61-82. DOI:https://doi.org/https://doi.org/10.32794/mr11250041.
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