Melatonin as an armament against non-steroidal anti-inflammatory drug induced gastric injury: An overview
Melatonin protects against NSAIDs
Keywords:
NSAIDs, cyclooxygenase, gastrointestinal tract, oxidative stress, tissue damage, melatonin, antioxidant
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely prescribed medicines to treat numerous pathophysiological conditions clinically. However, growing evidence indicates the adverse effects of NSAIDs on the different vital organs, among which gastrointestinal (GI) tract seems to be the utmost target in most of the cases. NSAIDs promote over production of harmful reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the gastric mucosa. These toxic species cause microvascular damage, increasing intestinal permeability, leading to the development of gastric lesions including ulcerations. Several strategies have been proposed to reduce the side effects of NSAIDs on the GI tissue, but most of them have failed to achieve this goal. Identification of an appropriate therapeutic strategy is urgently required. It is our opinion that this novel strategy to target GI damage induced by NSAID should include both anti-inflammatory and antioxidant properties. Under such a circumstance melatonin probably is the best choice for this purpose. Melatonin is a broad spectrum antioxidant and anti-inflammatory molecule. Numerous studies have reported the protective role of melatonin against gastric tissue damages caused by NSAIDs in animals or clinically. However, the underlying molecular mechanisms are not fully clarified. Thus, the present review attempts to gather the available information on this topic to provide a clear understanding on the exact scenario of this aspect.
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Published
2019-02-20
How to Cite
[1]
Pal, P., Bhattacharjee, B., Chattopadhyay, A. and Bandyopadhyay, D. 2019. Melatonin as an armament against non-steroidal anti-inflammatory drug induced gastric injury: An overview. Melatonin Research. 2, 1 (Feb. 2019), 115-137. DOI:https://doi.org/https://doi.org/10.32794/mr11250015.
Section
Reviews
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