Nanocarriers for melatonin delivery
Melatonin delivery
Keywords:
Melatonin, nanocarrier, nanoparticle, drug delivery system
Abstract
More attention has been drawn to the drug delivery systems to achieve more precise and efficient treatment for patients with less doses of medicines. The use of nanoparticles for drug delivery system has emerged for this purpose. It can enhance the treatment efficiency by use of the drugs more selectively and precisely to deliver them to the targeted organs or tissues. Drug delivery systems can also help to reduce the side effects, especially for the chemotherapeutic agents that have severe toxicity. Melatonin (N-acetyl-5-methoxytriptamine) is a small indolamine molecule that is produced by most cells and can influence on circadian manner. Melatonin also has antiapoptotic and antioxidant actions depending on the microenvironment; these actions are enhanced when it is incorporated into nanocarriers. Although the therapeutic effects of melatonin are promising, to achieve its optimal results is required. Therefore, the use of nanocarriers of melatonin is of clinical interest. Different melatonin loaded nanocarriers such as lipid-based nanocarriers, hybrid nanocarriers, synthetic ones, etc. can be used to deliver melatonin more efficiently for prevention or treatment of various diseases. In this review, we summarize the treatment efficiency of melatonin when it is incorporated into different nanocarriers.
References
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2. Jeevanandam J, et al. (2018) Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein J. Nanotechnol. 9: 1050-1074.
3. Stamatoiu O, et al. (2012) Nanoparticles in liquid crystals and liquid crystalline nanoparticles. Top. Curr. Chem. 318: 331-393.
4. Rakotoarisoa M, et al. (2019) Cubic liquid crystalline nanostructures involving catalase and curcumin: BioSAXS study and catalase peroxidatic function after cubosomal nanoparticle treatment of differentiated SH-SY5Y cells. Molecules 24 (17): 3058.
5. Chuffa LGA, et al. (2021) Melatonin-loaded nanocarriers: New horizons for therapeutic applications. Molecules 26 (12):3562.
6. Mir SM, et al. (2022) Melatonin: A smart molecule in the DNA repair system. Cell. Biochem. Funct. 40 (1): 4-16.
7. Mirza Aghazadeh Attari M, et al. (2020) Melatonin: an important anticancer agent in colorectal cancer. J. cell. physiol. 235 (2): 804-817.
8. Heydari N, et al. (2023) Melatonin: An anticancer molecule in esophageal squamous cell carcinoma: A mechanistic review. Melatonin Res. 6 (1): 59-71.
9. Targhazeh N, et al. (2022) Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy. Biochimie 202: 34-48.
10. Asanjani Oskoii M, et al. (2022) Serum level of melatonin in patients with osteoarthritis and its relation with 8-hydroxy-2-deoxyguanosine and vitamin D. J. Res Clin. Med. 8 (1): 34-34.
11. Wang S-Y, et al (2020) Indole-based melatonin analogues: Synthetic approaches and biological activity. Eur. J. Med. Chem. 185: 111847.
12. Pandi-Perumal SR, et al. (2008) Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog. Neurobiol. 85 (3): 335-53.
13. Mir SM., et al. (2020) The sensitization of melatonin in osteosarcoma cells by suppression of anti-apoptotic proteins. Pharm. Sci. 26 (2): 159-164.
14. Wade AG, et al. (2010) Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Med. 8: 51.
15. Zetner D, Rosenberg J (2020) Solubility and stability of melatonin in propylene glycol, glycofurol, and dimethyl sulfoxide. F1000Res. doi.10.12688/f1000research.21992.1. PPR: PPR11181.
16. Zhang Q, et al. (2017) Construction of nanoscale liposomes loaded with melatonin via supercritical fluid technology. J. Microencapsul. 34 (7): 687-698.
17. Molska A, et al. (2020) In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations. Eur. J. Pharm. Biopharm. 152: 248-256.
18. Lin W, et al. (2019) Poly-phosphocholinated liposomes form stable superlubrication vectors. Langmuir. 35 (18): 6048-6054.
19. Gonçalves MC, et al. (2012) Chitosan coated liposomes as an innovative nanocarrier for drugs. J. biomed. nanotechnol. 8 (2): 240-250.
20. Dubey V, et al. (2007) Melatonin loaded ethanolic liposomes: physicochemical characterization and enhanced transdermal delivery. Eur. J. Pharm. Biopharm. 67 (2): 398-405.
21. Marepally S, et al. (2013) Design, synthesis of novel lipids as chemical permeation enhancers and development of nanoparticle system for transdermal drug delivery. PLoS One 8 (12): e82581.
22. Sana S, et al. (2017) Vesicular melatonin efficiently downregulates sodium fluoride-induced rat hepato- and broncho-TNF-α, TGF-β expressions, and associated oxidative injury: a comparative study of liposomal and nanoencapsulated forms. Int. J. Nanomedicine. 12: 4059-4071.
23. Bseiso EA, et al. (2022) Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality. Drug Deliv. 29 (1): 2469-2480.
24. Hou X, et al. (2022) Application and efficacy of melatonin elastic liposomes in photoaging mice. Oxid. Med. Cell. Longev. 2022: 7135125.
25. Alsaad AA, Hussien AA, Gareeb MM, (2020) Solid lipid nanoparticles (SLN) as a novel drug delivery system: A theoretical review. Syst. Rev. Pharm. 11: 259-273.
26. López KL, et al. (2023) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) prepared by microwave and ultrasound-assisted synthesis: Promising green strategies for the nanoworld. Pharmaceutics 15 (5): 1333.
27. Albertini B, et al. (2014) Formulating SLMs as oral pulsatile system for potential delivery of melatonin to pediatric population. Int. J. Pharm. 469 (1): 67-79.
28. Musazzi UM, et al. (2019) A new melatonin oral delivery platform based on orodispersible films containing solid lipid microparticles. Int. J. Pharm. 559: 280-288.
29. Tursilli R, et al. (2006) Enhancement of melatonin photostability by encapsulation in lipospheres. J. Pharm. Biomed. Anal. 40 (4): 910-914.
30. Hatem S, et al. (2018) Clinical cosmeceutical repurposing of melatonin in androgenic alopecia using nanostructured lipid carriers prepared with antioxidant oils. Expert Opin. Drug Deliv. 15 (10): 927-935.
31. Rezzani R, et al. (2009) Melatonin delivery in solid lipid nanoparticles: prevention of cyclosporine A induced cardiac damage. J. Pineal Res. 46 (3): 255-261.
32. Mirhoseini M, et al. (2019) Protective effects of melatonin solid lipid nanoparticles on testis histology after testicular trauma in rats. Res. Pharm. Sci.. 14 (3): 201-208.
33. Sabzichi M, et al. (2016) Sustained release of melatonin: A novel approach in elevating efficacy of tamoxifen in breast cancer treatment. Colloids Surf. B. Biointerfaces 145: 64-71.
34. Parvez S, et al. (2023) Coalition of biological agent (melatonin) with chemotherapeutic agent (amphotericin B) for combating visceral leishmaniasis via oral administration of modified solid lipid nanoparticles. ACS Biomater. Sci. Eng. 9 (6): 2902-2910.
35. Aghaz F, et al. (2021) Enhanced cryoprotective effect of melatonin and resveratrol by coencapsulation: Improved in vitro development of vitrified-warmed mouse germinal vesicle oocytes. Biopreserv. Biobank 19 (3): 184-193.
36. Hallan SS, et al. (2016) Lipid polymer hybrid as emerging tool in nanocarriers for oral drug delivery. Artif. Cell. Nanomed. Biotechnol. 44 (1): 334-49.
37. Pohlmann AR, et al. (2010) Preparation of drug-loaded polymeric nanoparticles and evaluation of the antioxidant activity against lipid peroxidation. Methods Mol. Biol. 610: 109-121.
38. Carbone C, et al. (2016) Innovative hybrid vs polymeric nanocapsules: The influence of the cationic lipid coating on the "4S". Colloids Surf. B. Biointerfaces. 141: 450-457.
39. Komninou ER, et al. (2016) Effects of two types of melatonin-loaded nanocapsules with distinct supramolecular structures: Polymeric (NC) and lipid-core nanocapsules (LNC) on bovine embryo culture model. PLoS One 11 (6): e0157561.
40. Charão MF, et al. (2015) Protective effects of melatonin-loaded lipid-core nanocapsules on paraquat-induced cytotoxicity and genotoxicity in a pulmonary cell line. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 784: 1-9.
41. Jin K, et al. (2022) Anti-oxidative and mucin-compensating dual-functional nano eye drops for synergistic treatment of dry eye disease. Appl. Mater. Today 27: 101411.
42. Romeo A, et al. (2022) Melatonin loaded hybrid nanomedicine: DoE approach, optimization and in vitro study on diabetic retinopathy model. Int. J. Pharm. 627: 122195.
43. Ishaniya W, et al. (2022) Nano-encapsulation of melatonin into polydiacetylene-phospholipid assembly for sustained-release and enhanced bone formation in zebrafish. J. Drug Deliv. Sci. Technol. 72: 103415.
44. Duvnjak Romić M, et al. (2019) Melatonin loaded lipid enriched chitosan microspheres – Hybrid dressing for moderate exuding wounds. J. Drug Deliv. Sci. Technol. 52: 431-439.
45. Chen S, et al. (2019) Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications. Eur. J. Pharm. Biopharm. 144: 18-39.
46. Temprom L, et al. (2022) A novel preparation and characterization of melatonin loaded niosomes based on using a ball milling method. Mater. Today Commun. 31: 103340.
47. Arslan Azizoglu G, et al. (2017) Dual-prevention for UV-induced skin damage: incorporation of melatonin-loaded elastic niosomes into octyl methoxycinnamate pickering emulsions. AAPS Pharm. Sci. Tech. 18 (8): 2987-2998.
48. Priprem A, et al. (2018) Transmucosal delivery of melatonin-encapsulated niosomes in a mucoadhesive gel. Ther. Deliv. 9 (5): 343-357.
49. Damrongrungruang T, et al. (2020) Glutaryl melatonin niosome gel for topical oral mucositis: Anti- inflammatory and anticandidiasis. Curr. Drug Deliv. 17 (3): 195-206.
50. Uthaiwat P, et al. (2021) Oral administration of melatonin or succinyl melatonin niosome gel benefits 5-FU-induced small intestinal mucositis treatment in mice. AAPS Pharm. Sci. Tech. 22 (5): 200.
51. Bitar A, et al. (2012) Silica-based nanoparticles for biomedical applications. Drug Discov. Today 17 (19-20): 1147-1154.
52. Khattabi AM, Talib WH, Alqdeimat DA, (2018) The effect of polymer length on the in vitro characteristics of a drug loaded and targeted silica nanoparticles. Saudi Pharm. J. 26 (7): 1022-1026.
53. Chen J, et al. (2022) Development of melatonin nano-delivery systems to reduce cadmium accumulation in rice (Oryza sativa L.) seedlings: Insights from photosynthetic efficiency, antioxidative response and gene expression. Environ. Exp. Bot. 196: 104822.
54. Usman MS, et al. (2018) Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles. Molecules 23 (2): 500.
55. Niu G, et al. (2021) Melatonin and doxorubicin co-delivered via a functionalized graphene-dendrimeric system enhances apoptosis of osteosarcoma cells. Mater. Sci. Eng. 119: 111554.
56. Rahimi M, et al. (2022) Chitosan-based biomaterials for the treatment of bone disorders. Int. J. Biol. Macromol. 215: 346-367.
57. Saeed RM, Dmour I, Taha MO, (2020) Stable chitosan-based nanoparticles using polyphosphoric acid or hexametaphosphate for tandem ionotropic/covalent crosslinking and subsequent investigation as novel vehicles for drug delivery. Front. Bioeng. Biotechnol. 8: 4.
58. Hafner A, et al. (2011) Short- and long-term stability of lyophilised melatonin-loaded lecithin/chitosan nanoparticles. Chem. Pharm. Bull. (Tokyo) 59 (9): 1117-1123.
59. Hafner A, et al. (2009) Melatonin-loaded lecithin/chitosan nanoparticles: physicochemical characterisation and permeability through Caco-2 cell monolayers. Int. J. Pharm. 381 (2): 205-213.
60. Hafner A, et al. Lecithin/chitosan nanoparticles for transdermal delivery of melatonin. J. Microencapsul. 28 (8): 807-815.
61. Shokrzadeh M, Ghassemi-Barghi N (2018) Melatonin loading chitosan-tripolyphosphate nanoparticles: Application in attenuating etoposide-induced genotoxicity in HepG2 cells. Pharmacol. 102 (1-2): 74-80.
62. Jafari H, et al. (2021) Characterization of pH-sensitive chitosan/hydroxypropyl methylcellulose composite nanoparticles for delivery of melatonin in cancer therapy. Mater. Lett. 282: 128818.
63. Soni JM, et al. (2021) Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model. Mater. Sci. Eng. C. Matter. Biol. Appl. 124: 112038.
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Published
2023-12-31
How to Cite
[1]
Ahmadi Jazi, A., Mohammadzadeh, F., Amirkhanlou, S., Arab Bafarani, Z. and Mir, S.M. 2023. Nanocarriers for melatonin delivery. Melatonin Research. 6, 4 (Dec. 2023), 503-519. DOI:https://doi.org/https://doi.org/10.32794/mr112500165.
Section
Reviews
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