Melatonin and phase separation: potential interactions and significance

Melatonin regulation of biomolecular condensates

  • Doris Loh Independent http://orcid.org/0000-0002-1693-4081
  • Russel J Reiter Department of Cell Systems and Anatomy, UT Health, Long School of Medicine, San Antonio, Texas 78229, USA
DOI: https://doi.org/10.32794/mr112500128
Keywords: liquid‐liquid phase separation, biomolecular condensates, ATP, RNA, stress granules, cardiolipin, lipid raft, membrane fluidity, m6A modification

Abstract

This commentary explores the leading edge of current understanding of the potential interactions associated with melatonin and the regulation of membraneless organelles (MLOs) formed via liquid‐liquid phase separation (LLPS) presented in recently published hypothetical reviews. As the scientific community increasingly recognizes the relevance of biomolecular condensates as fundamental organizers and propellers of cellular biochemistry, and that LLPS may be the quintessential process that provides insight into elusive physiological and pathological cellular conditions, the ancient role of melatonin in this new and exciting framework of cellular biology must be fully realized to its maximum potential.

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Published
2022-06-30
How to Cite
[1]
Loh, D. and Reiter, R.J. 2022. Melatonin and phase separation: potential interactions and significance. Melatonin Research. 5, 2 (Jun. 2022), 186-191. DOI:https://doi.org/https://doi.org/10.32794/mr112500128.
Issue
Vol 5 No 2 (2022): Melatonin Research
Section
Commentary
DOI
https://doi.org/10.32794/mr112500128
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