Melatonin as a microenvironmental cue for parasite development inside the host
Melatonin interactions in the host-parasite relationship
Keywords:
melatonin, parasites, cAMP, analogs, malaria, receptor
Abstract
Throughout the evolutionary process, parasites have
acquired characteristics that function as survival mechanisms. It has been
reported that melatonin, a molecule present in virtually all living organisms,
has several roles in parasite biology such as preventing tissue damage,
regulating gene expression and inflammatory processes, and acting as a free
radical scavenger. Additionally,
melatonin produced by the hosts accelerates the intra-erythrocytic cycle of the
human malaria parasite Plasmodium falciparum and the rodent malaria
parasite P. chabaudi, respectively. These findings have recently led to
an increased research enthusiasm to find how melatonin influences the
biological cycle of parasites. Therefore, this review aims to gather and
analyze the potential relationships of host produced melatonin with the
parasites Plasmodium sp., Trypanosoma cruzi, Leishmania
spp., Toxoplasma gondii, Schistosoma mansoni, Opisthorchis viverrini, and Entamoeba
histolytica, respectively.
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Published
2022-04-08
How to Cite
[1]
Honorio, R.I., Dias, B.K.M., Przyborski, J.M. and Garcia, C.R. 2022. Melatonin as a microenvironmental cue for parasite development inside the host. Melatonin Research. 5, 1 (Apr. 2022), 84-100. DOI:https://doi.org/https://doi.org/10.32794/mr112500122.
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