Melatonin, macrophages and microbiota: Interactions

  • Russel J Reiter Department of Cell Systems and Anatomy, UT Health, Long School of Medicine, San Antonio, USA
DOI: https://doi.org/10.32794/mr112500119
Keywords: immunomodulation, T cells, macrophage polarization, bacterial infection

Abstract

This commentary summarizes and highlights the recent research reports of the group headed by Professor Wenkai Ren.  Their research has been focused in two important investigative areas, namely, the role of melatonin in the regulation of macrophage polarization and the functional implications of melatonin for the gastrointestinal microbiota.  Both these subjects are of high interest to melatonin biologists since both have significant implications in clinical and veterinary medicine.


References

1. Ren W, Liu G, Chen S, Yin J, Wang J, Tan B, Wu G, Bazer FW, Peng Y, Li T, Reiter RJ, Yin Y. (2017) Melatonin signaling in T cells: Functions and applications. J. Pineal Res. 62(3): e12394.
2. Xia Y, Chen S, Zeng S, Zhao Y, Zhu C, Deng B, Zhu G, Yin Y, Wang W, Hardeland R, Ren W. (2019) Melatonin in macrophage biology: Current understanding and future perspectives. J. Pineal Res. 66(2): e12547.
3. Xia Y, Zhan Q, Ye Y, Wu X, He F, Peng Y, Yi Y, Ren W. (2022) Melatonergic signaling instructs transcriptional inhibition of IFNGR2 to lessen IL-1β-dependent inflammation. Clin. Transl. Med. 12(2): e716.
4. Ren W, Wang P, Yan J, Liu G, Zeng B, Hussain T, Peng C, Yin J, Li T, Wei H, Zhu G, Reiter RJ, Tan B, Yin Y (2018). Melatonin alleviates weanling stress in mice: Involvement of intestinal microbiota. J. Pineal Res. 64 (2): e12488.
5. Yin J, Li Y, Han H, Chen S, Gao J, Liu G, Wu X, Deng J, Yu Q, Huang X, Fang R, Li T, Reiter RJ, Zhang D, Zhu C, Zhu G, Ren W, Yin Y (2021). Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high-fat diet-fed mice. J. Pineal Res. 65(4): e12524.
6. He F, Liu Y, Li P, Wu W, Xia Y, Zhang D, Li N, Peng Y, Zhu G, Hardeland R, Reiter RJ, Ren W. (2022) Melatonin inhibits Gram-negative pathogens by targeting citrate synthase. SCIENCE CHINA Life Sci. 65: dou.org/10.1007/s11427-021-2032-9.
7. Liu Y, Jia Y, Yang K, Tong Z, Shi J, Li R, Xiao X, Ren W, Hardeland R, Reiter RJ, Wang Z. (2020) Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens. Theranostics 10 (23):10697-10711.
Published
2022-03-23
How to Cite
[1]
Reiter, R.J. 2022. Melatonin, macrophages and microbiota: Interactions. Melatonin Research. 5, 1 (Mar. 2022), 52-54. DOI:https://doi.org/https://doi.org/10.32794/mr112500119.
Issue
Vol 5 No 1 (2022): Melatonin Research
Section
Commentary
DOI
https://doi.org/10.32794/mr112500119
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