SUPPLEMENTAL MATERIALS

Physiological signature

Functional groups:

· Virus gateways (54 genes): HIF1A, ATP6V1C1, S100A9, HSPA5, ATP6V1D, PPIA, HAT1, SLC16A7, CD44, HDAC2, GADD45GIP, FLT, SLC2A1, CYB5B, PTGES3, FURIN, BSG, HMGB2, PSENEN, APH1B, TLR3, SLC3A2, METTL4, ATP6V1E1, IL13RA1, ADAM10, NCSTN, PSEN1, NOD2, SLC16A4, NFATC4, ACE2, KDM5B, VWF, NFATC3, CLDN5, GP6, SPN, GAS5, DICER1, SLC16A8, CD34, NFAT5, APH1A, HMGB1, PECAM1, TMPRSS2, KAT2B, NXNL1, APOD, ITGA6, TIE1 and KDR.

· Intracellular traffic (66 genes): SLC16A3, RAB10, KPNA2, SLC16A1, SLC7A5, LMAN2, FKBP10, AP3B1, SIGMAR1, HEATR3, RAB18, FKBP15, GRPEL1, SLC16A7, FKBP1A, RAB2A, SRP72, NUP62, TMED5, POR, RAB1A, RAB7A, NUTF2, YIF1A, VTA1, GOLGA3, NUP155, NPC2, AP2M1, ERGIC1, FURIN, RAB8A, FKBP7, PCSK6, SLC30A7, SLC30A6, ARF6, RAB5C, SRP54, GOLGA2, KPNA3, NUP98, SLC3A2, AP2A2, REEP5, GCC1, GOLGA7, KPNA1, SLC16A4, SLC27A2, SLC30A9, NUP88, RTN4, RAB14, NUP214, SLC25A21, NUP54, SLC16A8, NUP153, REEP6, RALA, USP6NL, GORASP1, VPS39, GOLGB1 and SLC44A2.

· Transcription/(post)translation physiology (79 genes): NME1, PPIB, ATP6V1C1, SIL1, ERP44, HYOU1, NOL10, FKBP10, CCDC86, HEATR3, HSPA5, ATP6V1D, FKBP15, IMPDH2, PPIA, HAT1, EXOSC3, MRPS5, SRP19, DDX21, EXOSC5, FKBP1A, GTF2F2, RRP9, NUP62, HDAC2, EIF4E2, MRPS27, TOR1A, RBM28, TRMT1, MDFI, DDX10, EXOSC2, UBXN8, RAE1, FKBP7, TLE3, H2AFB1, PRIM2, PPIL3, PABPC1, NGLY1, EDEM3, POLA2, LARP1, OS9, SDF2, UGGT2, POLA1, EXOSC8, INTS4, PRIM1, EIF4H, RPL36, NFATC4, HTATSF1, MDN1, UPF1, LARP1B, MOV10, KDM5B, ERLEC1, LARP7, NEAT1, CRTC3, TPR, PTBP2, ATE1, LARP4B, ELF3, RBM41, KAT2B, AKAP8L, SNIP1, ZC3H7A, TLE1, ZNF503 and LUC7L3.

· Mitochondrial physiology (42 genes): BCKDK, HIF1A, ATP6V1C1, NDUFAF2, HYOU1, AP3B1, GPX1, ATP6V1D, ETFA, GRPEL1, ATP6V1A, TIMM8B, MRPS5, STOML2, TIMM10, TIMM9, NDUFAF1, MRPS27, COX8A, ATP6AP1, ALAS1, CYB5B, MRPS2, TOMM70A, ACAD9, ATP13A3, NDUFB9, TARS2, ACADM, BCS1L, GFER, ECSIT, FASTKD5, MRPS25, PITRM1, ATP1B1, PMPCA, PMPCB, CYB5R3, REEP6, AASS and USP54.

Table S1. Correlation between COVID-19-Signature (transcription level) and the MEL-Index in human normal lungs.

GENES	r	p	FDR

*CTSB*	-0.41646	2.21E-13	1.00E-10
*SLC16A3*	-0.41623	2.28E-13	1.03E-10
*BZW2*	-0.39233	6.35E-12	2.86E-09
*NME1*	-0.39134	7.24E-12	3.26E-09
*BCKDK*	-0.38833	1.08E-11	4.85E-09
*PPIB*	-0.38591	1.48E-11	6.61E-09
*RAB10*	-0.3706	1.04E-10	4.65E-08
*HIF1A*	-0.36968	1.17E-10	5.20E-08
*KPNA2*	-0.36716	1.60E-10	7.07E-08
*ATP6V1C1*	-0.3667	1.69E-10	7.47E-08
*SLC16A1*	-0.36092	3.40E-10	1.50E-07
*SLC7A5*	-0.34244	2.92E-09	1.28E-06
*SIL1*	-0.34236	2.94E-09	1.29E-06
*NDUFAF2*	-0.34224	2.99E-09	1.30E-06
*ERP44*	-0.33827	4.65E-09	2.03E-06
*HS2ST1*	-0.32955	1.21E-08	5.24E-06
*LMAN2*	-0.3295	1.21E-08	5.26E-06
*HYOU1*	-0.32675	1.63E-08	7.04E-06
*G3BP1*	-0.31754	4.26E-08	1.84E-05
*NOL10*	-0.31579	5.10E-08	2.19E-05
*MIF*	-0.31036	8.83E-08	3.78E-05
*S100A9*	-0.3095	9.63E-08	4.11E-05
*FKBP10*	-0.30839	1.08E-07	4.58E-05
*AP3B1*	-0.29563	3.72E-07	0.000157
*GPX1*	-0.29515	3.89E-07	0.000164
*CCDC86*	-0.2939	4.38E-07	0.000184
*SIGMAR1*	-0.29197	5.24E-07	0.00022
*HEATR3*	-0.29089	5.80E-07	0.000243
*HSPA5*	-0.2905	6.02E-07	0.000251
*ATP6V1D*	-0.28927	6.75E-07	0.000281
*RAB18*	-0.28763	7.85E-07	0.000326
*FKBP15*	-0.28492	1.01E-06	0.000416
*FTH1*	-0.28253	1.25E-06	0.000516
*ETFA*	-0.28241	1.26E-06	0.00052
*GRPEL1*	-0.2814	1.38E-06	0.000568
*ATP6V1A*	-0.27621	2.19E-06	0.000898
*IMPDH2*	-0.27125	3.38E-06	0.001381
*PPIA*	-0.26951	3.92E-06	0.001596
*CLIC1*	-0.26878	4.17E-06	0.001695
*HAT1*	-0.2685	4.28E-06	0.001732
*TYMP*	-0.26795	4.48E-06	0.001809
*GLA*	-0.26697	4.87E-06	0.001962
*PPT1*	-0.26194	7.43E-06	0.002971
*TIMM8B*	-0.26139	7.77E-06	0.003101
*EXOSC3*	-0.26054	8.34E-06	0.003319
*MRPS5*	-0.25879	9.63E-06	0.003822
*SRP19*	-0.25855	9.83E-06	0.003891
*PSMD8*	-0.25829	1.00E-05	0.003963
*SLC16A7*	-0.25728	1.09E-05	0.004294
*SCCPDH*	-0.25301	1.54E-05	0.006034
*DDX21*	-0.25286	1.56E-05	0.006091
*MMP9*	-0.25247	1.61E-05	0.006268
*HMOX1*	-0.25192	1.68E-05	0.00653
*HSBP1*	-0.25058	1.87E-05	0.007226
*CD44*	-0.24897	2.12E-05	0.008186
*EXOSC5*	-0.24858	2.19E-05	0.008421
*DCTPP1*	-0.2476	2.36E-05	0.009046
*STOML2*	-0.24506	2.88E-05	0.010998
*IL17RA*	-0.24456	2.99E-05	0.011397
*FKBP1A*	-0.2429	3.40E-05	0.012926
*S100P*	-0.24128	3.85E-05	0.014583
*GTF2F2*	-0.23894	4.60E-05	0.017377
*GDF15*	-0.23819	4.87E-05	0.018343
*RAB2A*	-0.2378	5.01E-05	0.018833
*SCARB1*	-0.23618	5.65E-05	0.021201
*TIMM10*	-0.2314	8.05E-05	0.029929
*SRP72*	-0.23094	8.33E-05	0.030886
*PDZD11*	-0.2309	8.35E-05	0.030886
*TIMM9*	-0.22712	0.00011	0.040055
*NQO1*	-0.22673	0.000113	0.040951
*PLAT*	-0.22656	0.000114	0.041333
*RRP9*	-0.22483	0.000129	0.046635
*ALG8*	-0.22473	0.00013	0.046828
*NUP62*	-0.22447	0.000133	0.047576
*HDAC2*	-0.22152	0.000163	0.058401
*TMED5*	-0.21948	0.000188	0.066929
*GGCX*	-0.21671	0.000228	0.080486
*EIF4E2*	-0.21526	0.000251	0.088446
*POR*	-0.21119	0.00033	0.114646
*RAB1A*	-0.20806	0.000406	0.140635
*RAP1GDS1*	-0.20802	0.000408	0.140635
*NDUFAF1*	-0.20511	0.000493	0.169113
*IL6*	-0.20494	0.000498	0.170472
*MRPS27*	-0.20319	0.000558	0.190262
*GNG5*	-0.2014	0.000626	0.212107
*COX8A*	-0.20123	0.000633	0.21387
*ACSL3*	-0.20026	0.000673	0.226672
*CHPF2*	-0.19972	0.000696	0.233869
*FAM162A*	-0.19849	0.000752	0.25196
*RAB7A*	-0.1979	0.000781	0.260805
*TOR1A*	-0.19566	0.000898	0.29722
*RBM28*	-0.19454	0.000962	0.317574
*ATP6AP1*	-0.19221	0.00111	0.364119
*NUTF2*	-0.19096	0.001197	0.391492
*YIF1A*	-0.18953	0.001305	0.424226
*VTA1*	-0.18931	0.001323	0.428541
*TRMT1*	-0.18887	0.001358	0.438615
*GADD45GIP1*	-0.18725	0.001496	0.480351
*FLT1*	-0.18051	0.00222	0.70599
*GHITM*	-0.18046	0.002226	0.70599
*CISD3*	-0.18037	0.002238	0.707092
*SLC2A1*	-0.17981	0.002311	0.72332
*ALAS1*	-0.17801	0.00256	0.798732
*NEU1*	-0.17547	0.002956	0.916369
*GOLGA3*	-0.17534	0.002977	0.919936
*MDFI*	-0.17505	0.003025	0.93172
*DDX10*	-0.17435	0.003146	0.962752
*EXOSC2*	-0.17051	0.003889	1
*ACTG1*	-0.16821	0.004406	1
*CYB5B*	-0.16801	0.004453	1
*NEDD8*	-0.16501	0.00523	1
*PTGES2*	-0.16469	0.005317	1
*GGH*	-0.16429	0.005431	1
*CENPF*	-0.1632	0.005752	1
*NUP155*	-0.16221	0.006059	1
*PVR*	-0.16088	0.006495	1
*NPC2*	-0.16036	0.006669	1
*QSOX2*	-0.15961	0.006934	1
*AP2M1*	-0.15948	0.006982	1
*ERGIC1*	-0.15792	0.007562	1
*IDE*	-0.15719	0.007847	1
*AGPS*	-0.15699	0.007926	1
*CHPF*	-0.15594	0.008361	1
*PTGES3*	-0.15557	0.008518	1
*MRPS2*	-0.15458	0.008951	1
*PRKACA*	-0.15383	0.009293	1
*FURIN*	-0.15273	0.009817	1
*RAB8A*	-0.15257	0.009896	1
*CUL2*	-0.15141	0.010476	1
*ZDHHC5*	-0.15088	0.010757	1
*POFUT1*	-0.15055	0.010931	1
*UBXN8*	-0.15024	0.011096	1
*CWC27*	-0.14943	0.011547	1
*RAE1*	-0.1492	0.011673	1
*BSG*	-0.1473	0.012798	1
*CD59*	-0.14711	0.012915	1
*HMGB2*	-0.14317	0.015571	1
*FKBP7*	-0.14247	0.016091	1
*TLE3*	-0.14129	0.016999	1
*TOMM70A*	-0.13958	0.018398	1
*ALG5*	-0.13892	0.018956	1
*PCSK6*	-0.13792	0.019843	1
*PPARG*	-0.13779	0.019959	1
*STC2*	-0.13676	0.020918	1
*SLC30A7*	-0.13554	0.022093	1
*LOXL1*	-0.13384	0.023836	1
*SLC30A6*	-0.13375	0.02393	1
*HS6ST2*	-0.13351	0.024192	1
*ADAMTS1*	-0.13279	0.024975	1
*ARF6*	-0.13269	0.025085	1
*CSTA*	-0.13196	0.025899	1
*RAB5C*	-0.13036	0.027776	1
*SRP54*	-0.12785	0.030947	1
*GRN*	-0.1278	0.031013	1
*ADAM9*	-0.12511	0.03476	1
*TMSB10*	-0.12399	0.036428	1
*FBN1*	-0.12333	0.037452	1
*H2AFB1*	-0.1223	0.039086	1
*ITGB1*	-0.12165	0.040144	1
*F2RL1*	-0.12088	0.041426	1
*DPY19L1*	-0.11687	0.048719	1
*PRIM2*	-0.11627	0.049885	1
*AGT*	-0.11622	0.049983	1
*RNF41*	-0.11572	0.050993	1
*CDK5RAP2*	-0.11369	0.055236	1
*TBK1*	-0.10721	0.070748	1
*TMEM97*	-0.1068	0.071836	1
*PPIL3*	-0.10505	0.07664	1
*ALG11*	-0.10423	0.078967	1
*PSENEN*	-0.10249	0.084127	1
*GOLGA2*	-0.10116	0.088246	1
*KPNA3*	-0.09775	0.099578	1
*PABPC1*	-0.09752	0.100378	1
*KPNA4*	-0.09701	0.102184	1
*NGLY1*	-0.0949	0.1099	1
*SPCS1*	-0.09394	0.11354	1
*NUP98*	-0.09274	0.118275	1
*APH1B*	-0.09257	0.118951	1
*IFI6*	-0.09244	0.11945	1
*DNMT1*	-0.09207	0.120938	1
*THTPA*	-0.09206	0.120997	1
*EDEM3*	-0.08927	0.132727	1
*LGALS3*	-0.08924	0.132874	1
*ITGAV*	-0.08866	0.135394	1
*ABCC1*	-0.08648	0.145306	1
*PKP2*	-0.08644	0.145495	1
*RHOA*	-0.08455	0.154551	1
*TLR3*	-0.08417	0.156421	1
*CAB39*	-0.08389	0.157811	1
*NPC1*	-0.08379	0.158312	1
*ACAD9*	-0.08365	0.159011	1
*POLA2*	-0.08302	0.162158	1
*LARP1*	-0.08246	0.165039	1
*GPX2*	-0.08208	0.166986	1
*IL6ST*	-0.08201	0.167346	1
*STOM*	-0.0818	0.168465	1
*OS9*	-0.08128	0.171197	1
*SLC3A2*	-0.08073	0.174087	1
*ATP13A3*	-0.07984	0.178914	1
*CD4*	-0.07942	0.181244	1
*DPH5*	-0.07806	0.188819	1
*AP2A2*	-0.07772	0.190804	1
*METTL4*	-0.07745	0.192329	1
*DNAJC11*	-0.07722	0.193674	1
*INS*	-0.07719	0.19384	1
*SDF2*	-0.07697	0.195094	1
*ATP6V1E1*	-0.07682	0.196011	1
*IL13RA1*	-0.0765	0.197869	1
*ADAM10*	-0.07375	0.214514	1
*NARS2*	-0.07083	0.233262	1
*TBCA*	-0.07082	0.23333	1
*UGGT2*	-0.07041	0.236062	1
*GPAA1*	-0.06802	0.252404	1
*CHMP2B*	-0.06575	0.268567	1
*NEK9*	-0.06239	0.293899	1
*PRKAR2A*	-0.06215	0.295726	1
*TMEM39B*	-0.06012	0.311808	1
*C1orf50*	-0.05985	0.314006	1
*FOXRED2*	-0.05854	0.324734	1
*REEP5*	-0.05823	0.327276	1
*PUSL1*	-0.05812	0.328253	1
*POLA1*	-0.05523	0.352908	1
*NCSTN*	-0.05438	0.360359	1
*COL6A1*	-0.05333	0.369722	1
*EXOSC8*	-0.05243	0.377831	1
*CHMP2A*	-0.0506	0.394774	1
*GCC1*	-0.04804	0.419122	1
*PSEN1*	-0.04765	0.422969	1
*NDUFB9*	-0.04688	0.430501	1
*SAAL1*	-0.04634	0.43581	1
*NOC4L*	-0.04145	0.485797	1
*SERPINB3*	-0.04099	0.490648	1
*INTS4*	-0.04094	0.491185	1
*XIAP*	-0.04006	0.500567	1
*CEACAM5*	-0.03957	0.505822	1
*FBN2*	-0.03535	0.552324	1
*DCAF7*	-0.03489	0.557525	1
*BRD4*	-0.03454	0.561443	1
*GOLGA7*	-0.03408	0.566647	1
*KPNA1*	-0.03405	0.567042	1
*MYCBP2*	-0.03363	0.571828	1
*PRIM1*	-0.03326	0.57604	1
*PIGS*	-0.0329	0.58023	1
*EIF4H*	-0.03221	0.588122	1
*GIGYF2*	-0.03178	0.593087	1
*PLAC8*	-0.03147	0.596703	1
*CEP135*	-0.03049	0.608233	1
*NOD2*	-0.02996	0.614441	1
*PTH*	-0.0298	0.616397	1
*EDN1*	-0.02963	0.618387	1
*NIN*	-0.02903	0.625567	1
*SLC16A4*	-0.0285	0.631806	1
*ENG*	-0.02766	0.641951	1
*SBNO1*	-0.02749	0.643948	1
*CEP250*	-0.02685	0.651729	1
*TARS2*	-0.02639	0.657285	1
*SLC27A2*	-0.0259	0.663248	1
*ACADM*	-0.02434	0.68237	1
*G3BP2*	-0.02369	0.690419	1
*BCS1L*	-0.02126	0.720812	1
*MOGS*	-0.02106	0.723361	1
*SLC30A9*	-0.0198	0.739301	1
*CLCC1*	-0.01793	0.763086	1
*GFER*	-0.01688	0.776637	1
*RPL36*	-0.01492	0.801927	1
*ZC3H18*	-0.01394	0.814761	1
*NUP88*	-0.01374	0.817394	1
*MARK2*	-0.01286	0.828894	1
*CEP350*	-0.01281	0.829516	1
*NFATC4*	-0.01253	0.833197	1
*MPHOSPH10*	-0.01242	0.834639	1
*RANBP2*	-0.01229	0.836285	1
*NDFIP2*	-0.01145	0.847422	1
*FAR2*	-0.01094	0.854167	1
*ITCH*	-0.00738	0.901243	1
*MDK*	-0.00712	0.904697	1
*MIPOL1*	-0.00675	0.909622	1
*GNB1*	-0.0062	0.917067	1
*VEGFA*	-0.00522	0.930056	1
*PIGR*	-0.00512	0.931375	1
*HTATSF1*	-0.0044	0.941011	1
*PLD3*	-0.00289	0.961224	1
*PIGO*	-0.00263	0.964727	1
*ACE2*	-0.00047	0.993694	1
*NAT14*	0.001688	0.977361	1
*SCAP*	0.006195	0.917071	1
*MDN1*	0.006656	0.910929	1
*RBX1*	0.006993	0.90644	1
*PTMA*	0.007454	0.900302	1
*ECSIT*	0.009142	0.877875	1
*REN*	0.009598	0.871832	1
*PDE4DIP*	0.010412	0.861074	1
*ERMP1*	0.011901	0.841454	1
*RTN4*	0.012488	0.833738	1
*UPF1*	0.01347	0.820886	1
*COMT*	0.014049	0.813325	1
*JAKMIP1*	0.018738	0.752788	1
*FASTKD5*	0.018962	0.749921	1
*LARP1B*	0.019677	0.740822	1
*NUP107*	0.023049	0.698417	1
*MOV10*	0.024453	0.681024	1
*RAB14*	0.024632	0.67882	1
*ALDH3A1*	0.024939	0.675044	1
*MRPS25*	0.02503	0.673931	1
*DEK*	0.025755	0.665042	1
*KDM5B*	0.026864	0.651556	1
*TUBGCP2*	0.029499	0.619954	1
*PITRM1*	0.032215	0.588092	1
*ERLEC1*	0.032668	0.582855	1
*ATP1B1*	0.033637	0.571713	1
*PMPCA*	0.033787	0.57	1
*TGFB1*	0.033874	0.569015	1
*INHBE*	0.03406	0.566887	1
*TYSND1*	0.036051	0.544431	1
*VWF*	0.03675	0.536647	1
*CLIP4*	0.038602	0.516308	1
*TBKBP1*	0.038692	0.515321	1
*TUBGCP3*	0.044351	0.455782	1
*SLC9A3R1*	0.044875	0.450471	1
*IFNA1*	0.045285	0.446341	1
*TRIM59*	0.047732	0.422137	1
*CST3*	0.048059	0.418959	1
*NFATC3*	0.051641	0.385092	1
*ACE*	0.05191	0.382622	1
*CLDN5*	0.053284	0.370137	1
*HOOK1*	0.054296	0.361104	1
*GP6*	0.055704	0.348768	1
*DSTN*	0.057028	0.337415	1
*MAP7D1*	0.057888	0.330168	1
*GRIPAP1*	0.058609	0.324163	1
*SPN*	0.058734	0.323136	1
*CSDE1*	0.060852	0.305962	1
*NUP214*	0.060935	0.305303	1
*GAS5*	0.062115	0.296009	1
*ERC1*	0.063089	0.28849	1
*LOX*	0.065333	0.271645	1
*CSNK2B*	0.06536	0.271453	1
*SLC25A21*	0.065896	0.267531	1
*SLU7*	0.06639	0.263954	1
*BAG5*	0.071299	0.230175	1
*FYCO1*	0.073518	0.215955	1
*TCF12*	0.075737	0.202379	1
*SEPP1*	0.075771	0.202178	1
*MTCH1*	0.079197	0.182463	1
*CAPSL*	0.07972	0.179579	1
*NLRX1*	0.080649	0.174546	1
*DNAJC19*	0.081462	0.170227	1
*PLD2*	0.081671	0.169129	1
*LARP7*	0.081758	0.168677	1
*NPPB*	0.082767	0.163465	1
*NPTX1*	0.082918	0.162691	1
*TNF*	0.08297	0.162431	1
*ARL6IP6*	0.084402	0.155273	1
*DICER1*	0.085168	0.151548	1
*NUP54*	0.085582	0.149561	1
*RIPK1*	0.085986	0.147642	1
*VPS11*	0.086537	0.145055	1
*ZYG11B*	0.086869	0.143512	1
*PMPCB*	0.087163	0.142154	1
*MAT2B*	0.087379	0.141169	1
*MARK1*	0.088975	0.134017	1
*MFGE8*	0.090043	0.129393	1
*CYB5R3*	0.094713	0.1106	1
*NFU1*	0.097425	0.100715	1
*DCAKD*	0.097925	0.098969	1
*TOR1AIP1*	0.098518	0.096933	1
*CD151*	0.100276	0.091091	1
*NFATC1*	0.100342	0.090875	1
*SMOC1*	0.101575	0.086958	1
*TM2D3*	0.101688	0.086604	1
*SPAG16*	0.106567	0.072453	1
*OPTN*	0.109596	0.064655	1
*ANO6*	0.109802	0.064151	1
*SLC16A8*	0.111075	0.061108	1
*SLC44A4*	0.112753	0.057276	1
*SIRT5*	0.113147	0.056407	1
*IL6R*	0.11328	0.056116	1
*TSPAN1*	0.118645	0.045367	1
*UBAP2L*	0.12209	0.03942	1
*USP13*	0.124304	0.035958	1
*CD34*	0.124431	0.035766	1
*NEAT1*	0.12491	0.035056	1
*AKAP8*	0.126961	0.032144	1
*PLA2G10*	0.127034	0.032045	1
*NUP153*	0.127327	0.031647	1
*REEP6*	0.127807	0.031006	1
*CRTC3*	0.128714	0.029823	1
*RALA*	0.129018	0.029435	1
*NFAT5*	0.130683	0.027387	1
*APH1A*	0.133563	0.024133	1
*TPR*	0.133836	0.023842	1
*PTBP2*	0.135224	0.022412	1
*CSNK2A2*	0.135711	0.021928	1
*CA2*	0.137972	0.019798	1
*IST1*	0.141523	0.016815	1
*HMGB1*	0.143877	0.015061	1
*UBAP2*	0.149209	0.011669	1
*ATE1*	0.150831	0.01078	1
*ZNF318*	0.15321	0.009586	1
*TFF3*	0.153293	0.009546	1
*USP6NL*	0.15341	0.009491	1
*CLDN3*	0.153847	0.009286	1
*CEP68*	0.155269	0.008648	1
*PECAM1*	0.157227	0.007833	1
*LARP4B*	0.159278	0.007053	1
*LAMB3*	0.160905	0.006485	1
*MEPCE*	0.163798	0.005574	1
*ELF3*	0.167432	0.004594	1
*TMPRSS2*	0.169056	0.004209	1
*SORBS2*	0.170178	0.00396	1
*CIT*	0.170364	0.00392	1
*RBM41*	0.17266	0.003455	1
*KAT2B*	0.17482	0.003065	0.94089
*NINL*	0.177143	0.00269	0.836507
*AKAP8L*	0.179877	0.002302	0.722827
*NXNL1*	0.180226	0.002256	0.710725
*MIB1*	0.181745	0.002067	0.659394
*GCC2*	0.184617	0.001748	0.559481
*APOD*	0.188553	0.001384	0.445777
*ITGA6*	0.189816	0.001283	0.418331
*CLDN4*	0.192921	0.001063	0.349636
*SNIP1*	0.196798	0.000836	0.277681
*EGFR*	0.197612	0.000795	0.264721
*PLEKHF2*	0.203192	0.000558	0.190262
*BRD2*	0.205384	0.000484	0.166588
*FBXL12*	0.211416	0.000325	0.113261
*ZC3H7A*	0.211958	0.000314	0.109546
*AASS*	0.212452	0.000304	0.106281
*GORASP1*	0.212715	0.000298	0.104719
*HECTD1*	0.216721	0.000227	0.080486
*ID4*	0.218854	0.000196	0.069698
*EPS15*	0.219647	0.000186	0.066348
*VPS39*	0.227016	0.000111	0.040234
*FAM8A1*	0.227878	0.000104	0.038085
*TLE1*	0.227894	0.000104	0.038085
*TIE1*	0.228615	9.85E-05	0.036255
*NFATC2*	0.228959	9.61E-05	0.035463
*ZNF503*	0.233729	6.78E-05	0.02533
*SEPSECS*	0.233749	6.77E-05	0.02533
*PCNT*	0.247644	2.35E-05	0.009038
*PDE5A*	0.251562	1.73E-05	0.006702
*PRKAR2B*	0.257081	1.11E-05	0.004353
*MARK3*	0.263999	6.25E-06	0.002508
*GOLGB1*	0.266484	5.07E-06	0.002039
*LUC7L3*	0.269552	3.91E-06	0.001594
*KDR*	0.293332	4.62E-07	0.000194
*FBLN5*	0.300646	2.30E-07	9.75E-05
*USP54*	0.30218	1.98E-07	8.42E-05
*SUN2*	0.312798	6.91E-08	2.97E-05
*TAPT1*	0.322906	2.44E-08	1.05E-05
*PLEKHA5*	0.343144	2.70E-09	1.19E-06
*AKAP9*	0.38692	1.30E-11	5.81E-09
*SLC44A2*	0.387422	1.22E-11	5.45E-09
*WFS1*	0.398271	2.85E-12	1.29E-09

Table S2. Top 40 most connected genes in the normal lung tissue Low, Medium, and High MEL-Index subgroups of the samples.

	MEL-Index
	Low	Medium	High
1	*TOR1A*	*REEP5*	*STOML2*
2	*SDF2*	*RAB14*	*NDUFAF1*
3	*ZDHHC5*	*COMT*	*EXOSC5*
4	*GPAA1*	*HDAC2*	*ALG5*
5	*STOML2*	*CYB5B*	*GHITM*
6	*RAE1*	*RAB5C*	*EIF4E2*
7	*ETFA*	*FBXL12*	*SLC30A6*
8	*GHITM*	*CHMP2A*	*TIMM8B*
9	*CISD3*	*CD151*	*ATP6V1D*
10	*MRPS2*	*PMPCB*	*VTA1*
11	*PIGO*	*PMPCA*	*CISD3*
12	*EIF4H*	*EIF4H*	*TOR1A*
13	*YIF1A*	*GHITM*	*MRPS2*
14	*ATP6V1E1*	*AP2M1*	*KDM5B*
15	*SPCS1*	*PSMD8*	*IST1*
16	*RAB5C*	*ZDHHC5*	*MRPS27*
17	*ATP6V1D*	*CYB5R3*	*PPT1*
18	*PUSL1*	*RAB7A*	*ACADM*
19	*DNAJC19*	*GNB1*	*ATP6V1E1*
20	*GTF2F2*	*SRP19*	*TMEM97*
21	*HDAC2*	*ERP44*	*TBK1*
22	*CHMP2A*	*ATP6V1E1*	*ATP6V1A*
23	*SCAP*	*OS9*	*NDUFB9*
24	*NDUFB9*	*RAP1GDS1*	*RRP9*
25	*NEDD8*	*RBX1*	*PIGO*
26	*PSMD8*	*EXOSC8*	*HTATSF1*
27	*RAB14*	*TOR1A*	*ERLEC1*
28	*COMT*	*SDF2*	*EXOSC2*
29	*REEP5*	*GPAA1*	*ETFA*
30	*VTA1*	*GORASP1*	*GRIPAP1*
31	*HTATSF1*	*GOLGA7*	*OPTN*
32	*GOLGA7*	*RHOA*	*PRIM1*
33	*MRPS27*	*QSOX2*	*BCS1L*
34	*PDZD11*	*ATP6AP1*	*ITGAV*
35	*NUP62*	*AKAP8*	*AGPS*
36	*RBX1*	*PUSL1*	*ALG8*
37	*VPS11*	*GNG5*	*LUC7L3*
38	*OS9*	*PTGES2*	*KPNA3*
39	*PIGS*	*TOMM70A*	*ACAD9*
40	*RNF41*	*BCKDK*	*SIGMAR1*

Table S3. Genes associated with ACE2 and CD147 virus gateways.

This work is licensed under a Creative Commons Attribution 4.0 International License

Please cite this paper as:

Fernandes, P.A., Kinker, G.S., Navarro, B.V., Jardim, V.C., Ribeiro-Paz, E.D., Córdoba-Moreno, M.O., Santos-Silva, D., Muxel, S.M., Fujita, A., Moraes, C., Nakaya, H.I., Buckeridge, M.S. and Markus, R.P. 2021. Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers. Melatonin Research. 4, 1 (Jan. 2021), 189-205. DOI:https://doi.org/https://doi.org/10.32794/mr11250090.